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Arthritis Biosea Health

Causes of Joint Pain

What does Joint Cartilage have in common with Potholes?

A good analogy of joint pain is that the cartilage between your joints is like a road with potholes. The roadway starts off perfect. Over time, with wear and tear, it gets small potholes and cracks.  We think our joints are perfectly fine, but actually, the car tyres are crossing over those small potholes. We don’t have pain and we are hopeful this will continue into old age.

But at some stage, and mostly unexpectedly, the potholes get so big, the car tyres cannot bridge those widening potholes and the car ride now is extremely bumpy. And painful. And no or very reduced mobility. Surgery fixes the potholes or puts in a whole new road!

Joint decline is not a straight line but most often is progressive and comes on suddenly but sometimes briefly (technically called episodic acute).  It generally gets worse as the deterioration continues. Pain is not from the cartilage, but nerves that are in the bones and soft tissues (e.g. capsules, and ligaments) around the joint. Damaged cartilage itself is relatively pain insensitive. The experience of pain from damaged and degenerating joints varies widely. Pain does not affect everyone the same way. Tests with X-rays and MRI scans don’t always correlate with pain or disability. The nervous system varies between people. Some have insensitive nervous symptoms and say they have little pain. Others are labeled as having a low pain threshold. We may say someone is “stoic” but it may just be they don’t have a sensitive nervous system. And pain may not be in the joint, but might be in an area well away from the joint itself.

It is estimated the correlation between pain and measurable damage is about 65% and physiotherapists will talk about a skeletal age versus organic aging. 

Degradation Curve of Joint Pain

At some stage, joints start to decline. We don’t notice for a long time but by mid thirties to mid fifties we notice aches and pains.

In our earlier years, most have healthy joints. Children have breaks, sprains, but most heal. 

We will consider important factors including early diagnosis, prevention, delay and cure.

By the 50’s we are contemplating surgery. By the 70’s we are filling up hospital surgeries. This does not include the cohort who suffer damage at 15 years of age, have surgery at 25, more surgery at 35 and by 45 are surgical curiosities! 

Osteoarthritis Costs You Dearly 

OA costs you money. As a consequence of symptoms and activity limitations, OA leads to medical costs and costs due to productivity loss of over $1,000  per patient per month, twice as much as other chronic diseases such as diabetes (Hermans et al. 2012)

3 Options to Reduce Joint Pain 

 In the figure above, we really only have 3 options to reduce joint pain.  

  • 1- Prevent
  • 2 – Delay
  • 3 – Cure
  1. Prevent joints declining. What are the things to do so that our joints are in good shape until we die? Taking pain killers for years is not prevention. It stops the pain but does nothing in terms of the physical damage that is occurring in the joints. 
  2. Delay – can you delay by 10 or 20 years with recommended lifestyle changes – remaining in the green zone of healthy joints, or at worse in the yellow zone, but with minor pain?
  3. Cure – Not everyone has the money for surgery or other new medical techniques.

1. Prevention – The Best Option

Some joint pain is inevitable. You cannot stop aging. Most physiotherapists & researchers say that the joints of the human body are good for maybe 55 years and then start to suffer measurable degradation. Joints wear out as the cartilage thins, bones reduce in strength.  However, joints do not wear out in a straight line fashion.  There are lifestyle choices to reduce the rate of wear. 

We think of joints as simply bone on bone with a cartilage in between, but it is more complex. The joint capsule consists of two layers, an outer fibrous layer, fibrous capsule, and an inner layer called the synovial membrane. The synovial membrane is a thin, vascular lining that covers the inner surfaces of the joint capsule and intra-articular ligaments and tendons.The lining of the capsule, the synovial membrane  makes synovial fluid which provides nutrition and lubrication.  

There are multiple causes of joint damage, leading to joint pain. In synovial joints, cartilage separates the two bones. The cartilage can fracture, but it is the other parts of the joint that get inflamed. 

Pain receptors are in the bone and the capsules that surround the joint.  There are many pain receptors in these structures, but relatively few pain receptors in the cartilage itself. As the bearing surface of the joint (cartilage) wears down, inflammation and pain sets in. 

2. Delay – The Next Best 5 Options.

There are 5 Simple Strategies to Delay Joint Pain

  1. Be Active.   The expression is if you don’t use it, you lose it. Walk 2 to 3 km per day, or swim, or do low impact exercises such as yoga or pilates. Low impact, consistent movement maintains not just joint health but overall health. One study showed walking more than 1 hour per day meant their medical care was $100,000 less over their lifetime and extended their life for 2 years. (Nagai et al. 2011) Adopting the popular High Intensity Technique (HIT exercise) will cause severe joint pain unless you spend months (or even up to 1 year if you are very deconditioned) getting the knees and joints strong enough to take that HIT energy. HIT is great for cardiovascular improvement but without preparation is also good for physiotherapists billing.
  2. Avoid employment that has heavy lifting or kneeling if you want to minimise OA (Ezzat and Li 2014)
  3. Avoid foods that cause inflammation and arthritis. There is lots of data recently that inflammation is a cause of arthritis (Kim et al. 2013) Excess added sugar is probably the primary cause of inflammation. Your diet should avoid sugar sweetened cereal, snack bars, pre-sweetened dairy products, canned fruit and condiments, particularly ketchup, BBQ sauce, honey mustard, French dressing, and similar. Do not eat any food that is more than 3% added sugar. The WHO recommendation is for less than 5% of diet or 25 grams (6 teaspoons) of added sugar in your diet per day! Purchase food from around the outside of the supermarket – fresh or frozen whole food. Avoid any centre isles. Alcohol consumption has not been reported as a cause! (Karlson et al. 2003) although excess consumption in animals is inflammatory. (Kc et al. 2015) 
  4. Manage your weight.  If you become overweight or obese with metabolic symdrome, evidenced by elevated blood pressure, elevated blood glucose levels, increased waist measure and elevated lipids then 75% will have joint pain, versus 25% if you are not. (3 times more). Obesity is a sign of an inflammatory diet. A study that looked at heavy physical work confirmed kneeling or squatting, heavy lifting and arm elevation did get about 30% more arthritis, but those with higher body mass, had higher rates of arthritis (Brennan-Olsen et al. 2018)
  5. Consume anti-inflammatory foods.  In a Nature paper on animal joints (Sekar et al. 2017), the addition of anti-inflammatory foods increased the amount of cartilage. When the animals ate an inflammatory diet which included long chain fatty acids, the animals got metabolic syndrome and osteoarthritis symptoms. When they ate antiflammatory materials, they did not get metabolic syndrome and their cartilage improved!. 

3. Is there a Silver Bullet for causes of Joint Pain?

There is no 100% certainty of “cure” for joint pain, especially when there has been a history of major joint trauma.  There are livestyle changes that can reduce pain and allow people to live with pain if it is not too severe. But people are often left on waiting lists.. If they have money or public health they will be able to get surgery. The typical “conservative” surgery is a technique that Germany calls “re-surfacing” where some of the wear parts are resurfaced, not replaced. The joints are complex, and often the ligaments and soft tissue remains, and may cause subsequent pain. Surgery has its own health risks and is often oversold as a cure. In UK, about 16% of women, 8% of men over 80 have had hip resurfacing or replacements. Surgery is not an absolute cure for joint pain, although with greater than 95% of patients experiencing significant but variable relief from hip pain. Experts disagree what constitutes “success” – pain, movement. The success rate of hip “replacements” 10 years after surgery has been optimistically measured at 90- 95% but at 20 years is down to 80-85%. Some unfortunately experience as much pain after surgery as before.

Seaweed Reduces Joint Pain

Understanding the causes of joint pain assist role of seaweed to reduce joint pain

Hundreds of customers have told us eating seaweed has reduced their joint pain. Some tell us that it has made no difference. 

We suspect the improvement depends one where you are on this joint degradation curve, genetics, diet, and what specifically is wrong.   

What Do the Experts Say

The CDC of USA (“5 Proven Ways to Manage Arthritis | CDC” 2019) says there are 5 Proven Ways to minimise Joint Pain. 

  1. Learn new self-management skills.
  2. Be active.
  3. Talk to your doctor.
  4. Manage your weight.
  5. Protect your joints.

Why do they recommend talking to your doctor?  With over 104 different types of arthritis, it is important to know which type you have. Is there a genetic cause? Have you played competitive sports or injured joints?  Are there other joint issues? There are genetic causes and there are other techniques and strategies for treatments. Their focus will be to reduce pain, minimize joint damage and improve or maintain function and quality of life. They can also assist with other chronic conditions, like diabetes or heart disease.

Note that in Europe and UK, you are likely to be referred to an inflammatory specialist, who will look at a range of conservative treatments, and who may then refer you to an orthopedic surgeon. In contrast, in USA or Australia you are likely to be directly referred to an orthopedic surgeon. 

Joint Pain – You are Not Alone

Joint pain (osteoarthritis or OA) is serious, and getting worse. The numbers are staggering. A recent report (Cui et al. 2020) looking at 10 million people says over 16% for those aged 15. It increases to 23% for those aged 40, and close to 70% if over 60. That’s over 600 million people aged over 40 years in 2020 worldwide. As people age, it gets worse. For elderly of 85+, in UK (Duncan et al. 2011) 65% had joint pain and women had more pain (69%) than men (58%) 

Some say that humans have a joint life of about 55 years. After that we are “the walking wounded”. But we also know joint pain is worse for anyone who does the high risk physical sports as explained below.  

Damage to Joints from High Impact Sports

Previously we have talked about the need to protect your joints from damage from an early age. Competitive sports that have sudden changes of direction, particularly in spiked shoes and with body contact are demonstrably higher risk and have long term consequences.(Short and Tuttle 2020)

People who do high performance sports activities with rapid change of direction are the most susceptible. Gymnasts , footballers, basketballers who play competitive sports into their 20’s or 30’s have between 5 to 20 times more surgery. (Vogel et al. 2011)

A surprising number of knee and hip joints are replaced each year and it has been known for decades that high impact sports are a major contributor to joint pain. Sports identified as high risk include::

  • Gymnastics – where the gymnast is coming down at speed onto mats or floors. Tennis also has rapid change of movement. 
  • Football – whether soccer, Rugby League (Gibbs 1994), Union, or American football.(Song et al. 2019; Gouttebarge, Aoki, and Kerkhoffs 2018). Those sports with spiked shoes and contact are the worst, so soccer is less risky than league or rugby which have both spiked shoes and body contact.
  • Playing competitive sports past mid 20’s.

The increase can be hundreds of times higher than the normal population.  The sports bodies have been reluctant to admit the potential for injury. (Khan et al. 2019) In 2018 (Gouttebarge, Aoki, and Kerkhoffs 2018) showed current and retired professional footballers were nearly twice as likely to suffer from knee OA by every additional severe knee injury and by every additional knee surgery they they incurred during their career. 

Anterior Cruciate Ligament Damage Increases OA

Cruciate ligaments are found inside your knee joint. They cross each other to form an “X” with the anterior cruciate ligament in front and the posterior cruciate ligament in back. The cruciate ligaments control the back and forth motion of your knee.

The anterior cruciate ligament (ACL) runs diagonally in the middle of the knee. It prevents the tibia from sliding out in front of the femur, as well as provides rotational stability to the knee. ACL damage is becoming more common. The damage when you do an ACL may not be just to the ligaments and surrounding tissue and ligaments. The damage may be more substantial.

Those who do an ACL, will almost certainly have osteoarthritis later in life. (Khan et al. 2019). A recent trend has seen a doubling of ACL injury in younger adults – which is thought to be a result of social drive to have young adults excel in sports (Zbrojkiewicz, Vertullo, and Grayson 2018). This will inevitably give rise to more OA in the next decades

.

Bone Bruising and Osteoarthritis Dissecans

Another cause of osteoarthritis is caused by bone bruising. ACL injuries may also occur in conjunction with bone bruising.  Sometimes sports people will suffer an ACL but also have OA dissecans, fix the ACL but still have ongoing bone bruising (Bredella et al. 2000)

Bone bruising

A typical cause of this injury used to be in the military where soldiers would jump off trucks with a fully laden pack, and wonder 15 years later why all the soldiers needed knee operations. Fortunately they followed the science. It also happens with people such as high jumpers or long jumpers. 

During rapid stopping, or during an ACL injury event, the scrunched bones in the joint get a “bone bruise”. The “bone bruise” is actually a fracture, results in a chalky area, and then repeated exercise opens up a hollow space in the bone. You get chronic inflammation from the irritation of the lining on the joint (the synovium) and it causes an increase of cells producing inflammatory fluid. It is called reactive synovitis or “water on the knee”.

Filling this hollow space with a lubricant (reactive synovitis) has gone out of favour but with good slow rehabilitation the  risk of subsequent OA is reduced. 

Cartilage – Not All the Same

Joints are complex. While babies start with 270 joints we have 206 named joints but with the inclusion of sesamoids which are are bones imbedded in tendons, but not connected to other bones. The patella (kneecap) is the largest sesamoid. These bones vary in number from person to person. So generally we have between 250 and 350 joints. (Barbe et al. 2009). Major joints – knee, ankle, elbows, wrists and shoulders are over-represented for pain. 

We think about bone, and cartilage and while the bones have the nerves, the cartilage keeps the bones apart and moving freely. There are different types of cartilage. And the layers that produce the cartilage are different. Technically, cartilage is classified as a special connective tissue with mesodermal origin characterised by a cellular component immersed within ECM composed of ground substance (polysaccharides), a fibrillar component (fibrous proteins), and interstitial fluid (mainly water). There is no direct supply of blood, lymphatics and nerves; nutrition relies on diffusion from the surrounding tissues. Based on the composition and function, it is possible to distinguish three types of cartilaginous tissues: hyaline, fibro- and elastic cartilage.(Armiento, Alini, and Stoddart 2019). With that complex of various bone, cartilage and connective tissue, specific identification and causes of pain can be difficult.

From Madhero88, CC BY-SA 3.0 <https://creativecommons.org/licenses/by-sa/3.0>, via Wikimedia Commons

Early Diagnosis & Causes of joint pain

A key part of AO treatment is early and proper diagnosis. The complexity of OA means that for many wrong diagnoses means incorrect treatment. The absence or presence of pain is a poor measure. When you consider a joint has a whole raft of connective tissue, cartilage, bones, synovial fluid, synovial tissue and OA may be identified as inflammation in other joints. There are various tests the physiotherapist/doctor/rheumatologist or orthopedic surgeon will do but there are also tests that have not been developed or identified yet.

The research by Prof Lindsay Brown and Prof Xiao say that restoration of cartilage and synovial membrane can be increased with anti-inflammatory functional food including seaweed. But if the damage from previous injuries is severe, restoration may take a longer time. Given there are 360 joints in the human body, any reduction in inflammation is welcome!

More Reading

Thanks to Greg Sheather (ret), Muscular Physiotherapist, Dip Phy Grad Dip Manipulative Therapy (Sydney) for the analogy of the potholes.

“5 Proven Ways to Manage Arthritis | CDC.” 2019. February 5, 2019. https://www.cdc.gov/arthritis/basics/management.htm.

Armiento, Angela R., Mauro Alini, and Martin J. Stoddart. 2019. “Articular Fibrocartilage – Why Does Hyaline Cartilage Fail to Repair?” Advanced Drug Delivery Reviews, Wound healing and fibrosis – State of play, 146 (June): 289–305. https://doi.org/10.1016/j.addr.2018.12.015.

Barbe, Mary, Jeffrey Driban, Ann Barr, Steven Popoff, and Fayez Safadi. 2009. “Structure and Function of Joints.” In Bone Pathology, 51–60. https://doi.org/10.1007/978-1-59745-347-9_2.

Bredella, M. A., P. F. Tirman, T. K. Wischer, J. Belzer, A. Taylor, and H. K. Genant. 2000. “Reactive Synovitis of the Knee Joint: MR Imaging Appearance with Arthroscopic Correlation.” Skeletal Radiology 29 (10): 577–82. https://doi.org/10.1007/s002560000259.

Brennan-Olsen, Sharon L., Svetlana Solovieva, Eira Viikari-Juntura, Ilana N. Ackerman, Steven J. Bowe, Paul Kowal, Nirmala Naidoo, et al. 2018. “Arthritis Diagnosis and Symptoms Are Positively Associated with Specific Physical Job Exposures in Lower- and Middle-Income Countries: Cross-Sectional Results from the World Health Organization’s Study on Global AGEing and Adult Health (SAGE).” BMC Public Health 18 (June). https://doi.org/10.1186/s12889-018-5631-2.

Cui, Aiyong, Huizi Li, Dawei Wang, Junlong Zhong, Yufeng Chen, and Huading Lu. 2020. “Global, Regional Prevalence, Incidence and Risk Factors of Knee Osteoarthritis in Population-Based Studies.” EClinicalMedicine 29–30 (December): 100587. https://doi.org/10.1016/j.eclinm.2020.100587.

Duncan, Rachel, Roger M. Francis, Joanna Collerton, Karen Davies, Carol Jagger, Andrew Kingston, Tom Kirkwood, Louise Robinson, and Fraser Birrell. 2011. “Prevalence of Arthritis and Joint Pain in the Oldest Old: Findings from the Newcastle 85+ Study.” Age and Ageing 40 (6): 752–55. https://doi.org/10.1093/ageing/afr105.

Ezzat, Allison M., and Linda C. Li. 2014. “Occupational Physical Loading Tasks and Knee Osteoarthritis: A Review of the Evidence.” Physiotherapy Canada. Physiotherapie Canada 66 (1): 91–107. https://doi.org/10.3138/ptc.2012-45BC.

Gibbs, Nathan. 1994. “Common Rugby League Injuries.” Sports Medicine 18 (6): 438–50. https://doi.org/10.2165/00007256-199418060-00007.

Gouttebarge, Vincent, Haruhito Aoki, and Gino M. M. J. Kerkhoffs. 2018. “Knee Osteoarthritis in Professional Football Is Related to Severe Knee Injury and Knee Surgery.” Injury Epidemiology 5 (1): 26. https://doi.org/10.1186/s40621-018-0157-8.

Hermans, Job, Marc A. Koopmanschap, Sita M. A. Bierma-Zeinstra, Joost H. van Linge, Jan A. N. Verhaar, Max Reijman, and Alex Burdorf. 2012. “Productivity Costs and Medical Costs among Working Patients with Knee Osteoarthritis.” Arthritis Care & Research 64 (6): 853–61. https://doi.org/10.1002/acr.21617.

Karlson, Elizabeth W, Lisa A Mandl, Gideon N Aweh, Oliver Sangha, Matthew H Liang, and Francine Grodstein. 2003. “Total Hip Replacement Due to Osteoarthritis: The Importance of Age, Obesity, and Other Modifiable Risk Factors.” The American Journal of Medicine 114 (2): 93–98. https://doi.org/10.1016/S0002-9343(02)01447-X.

Kc, Ranjan, Robin Voigt, Michael B Ellman, Xin Li, Keith C. Summa, Christopher B Forsyth, Ali Keshavarzian, Fred W. Turek, Jae-Sung Kim, and Hee-Jeong Im. 2015. “Chronic Alcohol Consumption Induces Osteoarthritis-Like Pathological Changes in an Experimental Mouse Model.” Arthritis & Rheumatology (Hoboken, N.J.) 67 (6): 1678–80. https://doi.org/10.1002/art.39090.

Khan, Tanvir, Abtin Alvand, Daniel Prieto-Alhambra, David J. Culliford, Andrew Judge, William F. Jackson, Brigitte E. Scammell, Nigel K. Arden, and Andrew James Price. 2019. “ACL and Meniscal Injuries Increase the Risk of Primary Total Knee Replacement for Osteoarthritis: A Matched Case-Control Study Using the Clinical Practice Research Datalink (CPRD).” British Journal of Sports Medicine 53 (15): 965–68. https://doi.org/10.1136/bjsports-2017-097762.

Kim, Jae-Sung, Michael B. Ellman, Dongyao Yan, Howard S. An, Ranjan Kc, Xin Li, Di Chen, et al. 2013. “Lactoferricin Mediates Anti-Inflammatory and Anti-Catabolic Effects via Inhibition of IL-1 and LPS Activity in the Intervertebral Disc.” Journal of Cellular Physiology 228 (9): 1884–96. https://doi.org/10.1002/jcp.24350.

Nagai, Masato, Shinichi Kuriyama, Masako Kakizaki, Kaori Ohmori-Matsuda, Toshimasa Sone, Atsushi Hozawa, Miyuki Kawado, Shuji Hashimoto, and Ichiro Tsuji. 2011. “Impact of Walking on Life Expectancy and Lifetime Medical Expenditure: The Ohsaki Cohort Study.” BMJ Open 1 (2): bmjopen. https://doi.org/10.1136/bmjopen-2011-000240.

Sekar, Sunderajhan, Siti Raihanah Shafie, Indira Prasadam, Ross Crawford, Sunil K. Panchal, Lindsay Brown, and Yin Xiao. 2017. “Saturated Fatty Acids Induce Development of Both Metabolic Syndrome and Osteoarthritis in Rats.” Scientific Reports 7 (46457): 11. https://doi.org/10.1038/srep46457.

Short, Steven, and Matthew Tuttle. 2020. “THE GAP BETWEEN RESEARCH AND CLINICAL PRACTICE FOR INJURY PREVENTION IN ELITE SPORT: A CLINICAL COMMENTARY.” International Journal of Sports Physical Therapy 15 (6): 1229–34. https://doi.org/10.26603/ijspt20201229.

Song, Kyeongtak, Erik A. Wikstrom, Joshua N. Tennant, Kevin M. Guskiewicz, Stephen W. Marshall, and Zachary Y. Kerr. 2019. “Osteoarthritis Prevalence in Retired National Football League Players With a History of Ankle Injuries and Surgery.” Journal of Athletic Training 54 (11): 1165–70. https://doi.org/10.4085/1062-6050-421-18.

Vogel, Laura A., Giuseppe Carotenuto, John J. Basti, and William N. Levine. 2011. “Physical Activity After Total Joint Arthroplasty.” Sports Health 3 (5): 441–50. https://doi.org/10.1177/1941738111415826.

Zbrojkiewicz, David, Christopher Vertullo, and Jane E. Grayson. 2018. “Increasing Rates of Anterior Cruciate Ligament Reconstruction in Young Australians, 2000–2015.” Medical Journal of Australia 208 (8). https://www.mja.com.au/journal/2018/208/8/increasing-rates-anterior-cruciate-ligament-reconstruction-young-australians.

Categories
Biosea Health Health Benefits

Seaweed Cake for Guilt Free Treat

Some additional food for thought: seaweed at the best with this recipe for seaweed cake – from the late Prof Isabelle Abbott who was a pioneer in seaweed from the University of Hawaii.

Ingredients

  • 1 1/2 cups salad oil
  • 2 cups sugar
  • 3 eggs
  • 2 cups grated or chopped seaweed: sea palm (Nereocystis), ogo (Gracilaria coronopifoloia), guso (Eucheuma or Kappaphycus) which is a local species from Hawaii and many tropical seas, including the Philippines. You could use a local equivalent. For this recipe, use about 1 tablespoon of dry Pacific Seamoss powder – as it swells up 15 x it is about the same as 2 cups)
  • 2 cups grated carrots
  • 1 cup crushed, drained pineapple (or 1 cup grated coconut, fresh)
  • preferably 2 1/2 cups flour
  • 1 teaspoon baking soda
  • 1 teaspoon salt
  • 1 teaspoon cinnamon
  • 1 cup chopped walnuts (optional)

Method for Seaweed Cake

  • Mix well the sugar and salad oil.
  • Add the eggs, one at a time, beating well after each egg is added.
  • Add the seaweed, carrots, and pineapple (or coconut).
  • Sift together the flour, baking soda, salt, mix well.
  • Add the chopped walnuts.
  • Bake in oblong pan or loaf pan at 350 degrees 45-50 minutes.
  • Serve plain or with buttercream frosting. A moist cake which keeps very well.

Recipe source

Marine algae expert Isabella Aiona Abbott broke barriers during her long career as a scientist, author, and university professor. She is thought to be the first Native Hawaiian person to earn a PhD in science. She was the first woman and first person of color to become a full Professor of Biology at Stanford University. After teaching at Stanford from 1960–1982, she retired and pursued a second career as professor of botany at the University of Hawaiʻi at Mānoa. Abbott established the University’s undergraduate major in Ethnobotany.

Reference

Womens History – Prof Isabella Abbot who died in 2010

Wikipedia Details of Professor Abbot

Other Recipes for Seaweed

Try the sourdough bread recipe on this page

For another guilt free way to consume seaweed try this chocolate recipe

Categories
Biosea Health Health Benefits

Sleep Better with Seaweed

Sleep is a complex process, but we have many customers who say they sleep better with Seaweed. What? Why? So we dug back through our customer referrals and data from our trials and it turns out there may improvement in sleep. Sleep is not just duration – importantly the patterns of sleep determine how you feel about sleep.

What Customers Say

My new neighbour is an 72 year old engineer with dodgy knees. After a month he says his knees “might” be better, but he has been sleeping better. Not waking at 3am. And that’s enough for him to keep going for another couple of months.

We saw a 50% improvement score in our dysmenorrhea trial but did not think too much about. It made sense if period pain was reduced. It was not something we had really focused on, but participants reported that after seaweed they did not loose work or social activities and it may be that they actually slept better.

Data from 150 women after 8 weeks of eating seaweed.

A number of our testimonials say they feel better on seaweed

Does More Exercise Improve Sleep

The data shows the women in the trial had more energy, and found it easier to exercise. And there are many studies that show more exercise helps sleep patterns -just don’t do the exercise immediately prior to sleep! We don’t know if they had small incremental changes in exercise.

Reduced inflammation

Seaweed is a powerful anti-inflammatory functional food. Does the improvement in inflammation help sleep?

Neuronal Effect

We know from seaweed studies that it builds better brain pathways for people with dementia and may have some action with diseases such as Parkinsons? Do the improvement neural pathways led to better sleep.

Sleep Better with Seaweed – The Role of Vitamins and Minerals

A number of vitamins and minerals help sleep – and check out our vitamins (here) and minerals (here) of things we know help sleep.

  • Iron. Iron is a major component in our blood that provides oxygen to our cells and tissues. Seaweed is a good source of naturally available Fe.
  • Magnesium. Magnesium is a mineral that works wonders when it comes to releasing tension and helping you and your muscles to relax. Pacific Seamoss has some.
  • Vitamin D Other kelps and brown seaweeds have Vitamin D but Pacific Seamoss does not.
  • Melatonin, but melatonin is not in seaweed.
  • Tryptophan – in reasonable amounts – helps sleep
  • B vitamins. Seaweed is chock full of B3.
  • Calcium. There is not much Ca in Seaweed.
  • Vitamin E. Our Pacific
  • Potassium. K helps smooth muscle relax. Over 95% of westerners are deficient in K.

Further Reading

The Mayo clinic: 6 Tips to help you Sleep Better

  1. Stick to a sleep schedule. Set aside no more than eight hours for sleep
  2. Pay attention to what you eat and drink. Don’t go to bed hungry or stuffed
  3. Create a restful environment. Create a room that’s ideal for sleeping.
  4. Limit daytime naps.
  5. Include physical activity in your daily routine.
  6. Manage worries.
Categories
Biosea Health Gout Health Benefits

Seaweed Reduces Gout

In a novel study published in March 2021, a team of Chinese researchers looked at 32,000 men and women and showed that seaweed reduces gout (hyperuricemia or HUA) in men. The association was not shown for women.

What is Gout?

Gout is a common and complex form of arthritis that can affect anyone. It’s characterized by sudden, severe attacks of pain, swelling, redness and tenderness in one or more joints, most often in the big toe.

An attack of gout can occur suddenly, often waking you up in the middle of the night with the sensation that your big toe is on fire. The affected joint is hot, swollen and so tender that even the weight of the bedsheet on it may seem intolerable.

Gout symptoms may come and go, but there are ways to manage symptoms and prevent flares. One of the markers looked at are levels of uric acid, as uric acid is the end product of purine metabolism. Increased production or reduced excretion of serum uric acid level causes hyperuricemia (HUA) and gout [2]. Gout is related to age and BMI and there are many societal behaviours that appear to change incidence and severity of gout.

For the past 30 years, it is known that most patients with HUA are asymptomatic and do not receive treatment. As Zang and the team point out, HUA is the causative agent of gout [3], and is an independent risk factor for cardiovascular events [4, 5], hypertension [6], diabetes [7], cancer [8] and renal disease [9], and independently predicts myocardial infarction and premature death [10].

We know from other animal studies and human trials that seaweed reduces high blood pressure.

Study shows seaweed reduces gout Serum markers

A study of 32,365 adults in Tianjin in China, published in Mar 2021 [1] looked at the food that the men and women ate, the frequency of seaweed eaten and the correlation with hyperuricemia.

Hyperuricemia was defined as serum uric acid levels ≥7.0mg/dL in men and ≥6mg/dL in women.

The prevalence of HUA was 21% in men and 6% in women. Men had higher BMI, more likely to be smokers and drinkers, had elevated cholesterol markers, ate more sweet food and more meat. Compared with females, males were more highly educated, were more likely to be managers, had a higher income, and had a higher prevalence of hypertension, hyperlipidemia, and diabetes

What they found was for men that the more seaweed eaten, the lower the uric acid levels.

Eat more seaweed – it will help reduce gout.

References

  1. Zhang, T., Wang, Y., Gu, Y., Meng, G., Zhang, Q., Liu, L., Wu, H., Zhang, S., Wang, X., Sun, S., Wang, X., Zhou, M., Jiao, H., Jia, Q., Song, K., Wu, Y., Wu, X. H., & Niu, K. (2021). Title: Relationship between seaweeds consumption and hyperuricemia in general adults: A Population-based Study from the TCLSIH Cohort Study. The British journal of nutrition, 1–31. Advance online publication. https://doi.org/10.1017/S0007114521000891
  2. Garrel DR, Verdy M, PetitClerc C, Martin C, Brule D, Hamet P. Milk- and soy-protein ingestion: acute effect on serum uric acid concentration. Am J Clin Nutr. 1991;53(3):665-9. Epub 1991/03/01. doi: 10.1093/ajcn/53.3.665. PubMed PM ID: 2000819
  3. Choi HK, Mount DB, Reginato AM, American College of P, American Physiological S. Pathogenesis of gout. Ann Intern Med. 2005;143(7):499-516. Epub 2005/10/06. doi: 10.7326/0003-4819-143-7-200510040-00009. PubMed PMID: 16204163.
  4. Hoieggen A, Alderman MH, Kjeldsen SE, Julius S, Devereux RB, De Faire U, et al. The impact of serum uric acid on cardiovascular outcomes in the LIFE study. Kidney international. 2004;65(3):1041-9. doi:10.1111/j.1523-1755.2004.00484.x. PubMed PMID: 14871425.
  5. Holme I, Aastveit AH, Hammar N, Jungner I, Walldius G. Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). Journal of internal medicine. 2009;266(6):558-70. doi: 10.1111/j.1365-2796.2009.02133.x. PubMed PMID: 19563390.
  6. Sundstrom J, Sullivan L, D’Agostino RB, Levy D, Kannel WB, Vasan RS. Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence. Hypertension. 2005;45(1):28-33. doi: 10.1161/01.HYP.0000150784.92944.9a. PubMed PMID: 15569852.
  7. Bhole V, Choi JW, Kim SW, de Vera M, Choi H. Serum uric acid levels and the risk of type 2 diabetes: a prospective study. Am J Med. 2010;123(10):957-61.
  8. Strasak AM, Rapp K, Hilbe W, Oberaigner W, Ruttmann E, Concin H, et al.
    Serum uric acid and risk of cancer mortality in a large prospective male cohort. Cancer causes & control : CCC. 2007;18(9):1021-9. doi: 10.1007/s10552-007-9043-3. PubMed PMID: 17665312.
  9. Obermayr RP, Temml C, Gutjahr G, Knechtelsdorfer M, Oberbauer R,
    Klauser-Braun R. Elevated uric acid increases the risk for kidney disease. Journal of the American Society of Nephrology : JASN. 2008;19(12):2407-13. doi: 10.1681/ASN.2008010080. PubMed PMID: 18799720; PubMed Central PMCID: PMC2588108.
  10. Fang J, Alderman MH. Serum uric acid and cardiovascular mortality the
    NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. Jama. 2000;283(18):2404-10. doi: 10.1001/jama.283.18.2404. PubMed PMID: 10815083.
  11. Uaratanawong S, Suraamornkul S, Angkeaw S, Uaratanawong R. Prevalence of hyperuricemia in Bangkok population. Clinical rheumatology. 2011;30(7):887-93. doi: 10.1007/s10067-011-1699-0. PubMed PMID: 21302126
Categories
Antiviral Biosea Health Health Benefits

Seaweed Nasal Spray Reduces Virus Infection

Most cold medicines only treat the symptoms; however, seaweed nasal spray attacks a cold at its source and is clinically proven to shorten the duration of a cold and help reduce the severity of cold symptoms. The are formulated to be preservative & steroid free, and can used during pregnancy, breastfeeding and kids from 12 months.

These solutions often have the natural ingredient iota-carragenan sourced from red seaweeds such as Eucheuma cottonii . Some may use the carrageenan Kappaphycus alvarezii . The carrageenan forms a barrier in the nasal passage that traps cold viruses, helping to reduce their multiplication and spread, allowing your body’s natural defences to sweep the viruses away from the nasal lining.

Seaweed Nasal Spray is in Multiple Products

These come in from a range of providers.

  • The Austrian company from Vienna Marinomed AG has produced a carrageenan product used by various called Carrogelose and that product is sold for colds and flus.
  • Flo Travel Nasal Spray from Entech
  • Mundicare® Cold Defence Nasal Spray from Mundipharma and they also sell a range of other natural products including melaleuca.
  • Sinomarin Plus Algae from Sinomarin from Greece, which uses the brown seaweed fucoidan extract Undaria pinnatifida and Spirulina plantensis/ Their product is for rhinitis, allergies and colds and flus.

Marinome published work in 2021 showing efficacy on SARS-COVID-2 with trials in Argentina. See this preliminary press release and the report from the Argentina hospital here

Seaweed extract reduces virus infection and impact
A range of products from Sinomarin as part of seaweed extracts in nasal sprays.

Is Whole Seaweed Effective?

For over 50 years, seaweed has been known to be effective as an antiviral compound and even tested against remdesivir in 2021. But the introduction and widespread sale of commercial products is a welcoming sign.

Marinome say a particular advantage of their carrageenan type product is the broad activity of the polymer against different virus strains, such as rhinovirus and colds and flus. They also show activity against coronaviruses. In clinical trials with more than 600 patients suffering from early symptoms of the common cold they show great improvement. Products containing their extracts, such as nasal sprays, lozenges or a throat spray have been marketed in Austria since 2008 and now have been established as the first causative treatment of common cold and flu-like diseases worldwide and are distributed in more than 40 countries.

Biosea Health suspects that the consumption of seaweed as a daily food will be effective in reducing the impact of viruses. That it reduces disease load in pigs and chickens in meat broiler and egg production is demonstrated. Research is needed to confirm.

Categories
Alzheimer's Disease Biosea Health Heart Health

Healthy Heart Reduces Dementia

A recent study published in PLOS showed a healthy heart reduces dementia in a cohort of about 1500 Finish people. Improvements in heart health in midlife reduced dementia risk. It was the latest study finding people with better cardiovascular health metrics scores in midlife had a significantly lower risk of late-life dementia.

More than 5 million adults aged 65 years and older in the United States are predicted to have dementia, with projected increases to nearly 14 million people by 2050. In Australia, it affects about 1 in 15 over the age of 65. The cost is more than $15 billion and costs about $35,000 per sufferer. [4] It is not a “normal” part of aging. Lifestyle makes a big difference.

Severe cognitive dysfunction involving difficulties with memory, recognition, language, decision making, attention, and problem-solving accompanies dementia. This can interfere with a person’s daily functioning.

The Healthy Heart Reduces Dementia Study

Dementia is a long term disease and this cohort study included 1,449 participants from the Finnish Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study, who were followed from midlife (baseline from1972 to 1987; mean age 50.4 years; 62.1% female) to late life (1998), and then 744 dementia-free survivors were followed further into late life (2005 to 2008). (30 year study)

Outcomes

The dementia rate was about 3.8% over a 20-year cumulative incidence for a healthy heart regime. If you had an unhealthy profile the risk of increase of dementia by about 3 times (to 9% over those 20 years)

Some lifelong modifiable risk factors identified in epidemiological studies, including cardiovascular risk factors from mid to late life, play a crucial role in the onset and progression of dementia. Seaweed reduces blood pressure and decreases heart inflammation in animal studies.

In fact, simulation research estimates that up to 35% of dementia cases may be due to modifiable risk factors across the life span. These risk factors include social and mental health factors such as education, social engagement, hearing loss, and depression.

Epidemiological studies also show the importance of cardiovascular health in the prevention of dementia. Factors such as smoking, diabetes, heart failure, atrial fibrillation, high blood pressure, obesity, and high cholesterol are all associated with an increased risk of dementia.

The American Heart Association’s (AHA) has 7 cardiovascular health metrics and four are behavioral:

  • physical activity
  • diet
  • smoking
  • body weight

Three components are biological:

  • blood cholesterol
  • blood pressure
  • blood glucose

Scientists have associated having ideal cardiovascular health metrics in midlife with a reduced incidence of dementia in later life.

Seaweed Reduces Dementia

In animal studies seaweed reduces dementia – but the translation from lab to human use is not direct. However there is enough evidence that the models are sound. This study concluded a healthy heart reduces dementia and there is data that seaweed reduces hypertension and diabetes – both major risk factor to dementia.

Dementia

References

[1] Liang Y, Ngandu T, Laatikainen T, Soininen H, Tuomilehto J, Kivipelto M, et al. (2020) Cardiovascular health metrics from mid- to late-life and risk of dementia: A population-based cohort study in Finland. PLoS Med 17(12): e1003474. https://doi.org/10.1371/journal.pmed.1003474

[2] [1] Wanyonyi, S; du Preez, R; Brown, L; Paul, N; Panchal, S  2017 Kappaphycus alvarezii as a Food Supplement Prevents Diet-Induced Metabolic Syndrome in Rats. Nutrients (9) 11 DOI:10.3390/nu9111261 (Click for Abstract) (Click to download full paper)

[3] Bogie, J et al (Including Monique Mulder) 2019 Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer’s disease mouse model. Scientific Reports 9 (1) DOI 10.1038/s41598-019-41399-4 (Click for Abstract) (Click to download full paper)

[4] Dementia – an overview. Healthdirec facts https://www.healthdirect.gov.au/dementia-overview

Categories
Arthritis Biosea Health Health Benefits

Stop Arthritis with Seaweed FAQ

The question is can you stop Arthritis with seaweed. We have many customers who report their symptoms have reduced and that seaweed is very effective. This may be due to the type of arthritis, and the amount of Pacific Seamoss seaweed that customers are consuming.

Is seaweed good for Arthritis

Seaweded is packed full of a large number of nutrients and vitamins which probably reduce the symptoms of arthritis. Nutrients such as potassium (K) are in high quantities and improve smooth muscle

Does seaweed work for All Types of arthritis

Arthritis is over 100 different types, and a large number of causes with not enough research done on the type of arthritis and the beneficial effects of seaweed.

Is Seaweed inflammatory

Seaweed is highly anti-inflammatory. In an animal experiment in 2017 and 2020, Brown looked at various markers such as hypertension, heart inflammation, gut inflammation, fatty liver inflammation and gut microbiota and glucose intolerance and seaweed reduced the the markers. Along with blood serum markers, the histological evidence was conclusive.

Effectiveness of Whole Seaweed versus Seaweed Extracts

The seaweed extract nutrient complex when taken orally over twelve weeks decreased the symptoms of osteoarthritis in a dose-dependent manner in 2007, and 2010,

How Common is Osteoarthritis

Osteoarthritis (OA) is the most frequent cause of disability among adults in the developed world. Arthritis affects around 15% in Australia (3 million people). More than 20 million people in the United States have the disease. The lifetime risk of knee OA for males and females aged over 45 years is between 45% (nonobese) to 70% for obese. The cost in USA is more than $60 billion per year.It is second only to ischemic heart disease as a cause of work disability for men over 50 years.

Can osteoarthritis Be Cured?

The progressive deterioration of articular cartilage which occurs in OA results in pain, stiffness and difficulty with physical activities. The disease is managed rather than cured, with a focus on pain relief.

What Natural Medicines are Used?

A number of herbal medicines in clinical trials show beneficial effects in reduction of OA symptoms. These include advocado, soybean unsaponifiables, lipids from green-lipped mussels, calcified seaweed extracts, and Pycnogenol (French maritime pine bark extract). Boswellia serrata extracts have also show clinical promise as do preparations of Harpagophytum procumbens (Devil’s Claw).
In vitro studies polyphenols such as epigallocatetchin (from green tea) and phlorotannin-rich extracts of the seaweed Ecklonia cava show potential.

Can you Stop Arthritis with Seaweed

Previous studies focused on seaweed extracts, not whole seaweed. The study by Myers was with a fucoidan extract and showed promise in Phase 1 / II trials but did not in phase 3 trials. When you look further, there is a strong dose rate up to 1g per day. Pacific Seamoss (see seaweed species here) is consumed at 2 to 5 grams per day. This consumption equivalent to a bowl of salad provides nutrients and vitamins, changes gut microbiota.

What are the Types of Arthritis?

From Appendix 1 of Arthritis Org which provides a list of Arthritis
Adult-onset Still’s Disease
Myositis
Ankylosing Spondylitis
Osteoarthritis (OA)
Back Pain
Osteoporosis
Behçet’s Disease
Pagets
Bursitis
Palindromic Rheumatism
Calcium Pyrophosphate Deposition Disease (CPPD)
Patellofemoral Pain Syndrome
Carpal Tunnel Syndrome
Pediatric Rheumatic Diseases
Chondromalacia Patella
Pediatric SLE
Chronic Fatigue Syndrome
Polymyalgia Rheumatica
Complex Regional Pain Syndrome
Pseudogout
Cryopyrin-Associated Periodic Syndromes
Psoriatic Arthritis (PsA)
Degenerative Disc Disease
Raynaud’s Phenomenon
Developmental-Dysplasia of Hip
Reactive Arthritis
Ehlers-Danlos
Reflex Sympathetic Dystrophy
Familial Mediterranean Fever
Reiter’s Syndrome
Fibromyalgia
Rheumatic Fever
Fifth Disease
Rheumatism
Giant Cell Arteritis
Rheumatoid Arthritis (RA)
Gout
Scleroderma
Hemochromatosis
Sjögren’s Syndrome
Infectious Arthritis
Spinal Stenosis
Inflammatory Arthritis
Spondyloarthritis (SpA)
Inflammatory Bowel Disease
Systemic Juvenile Idiopathic Arthritis (sJIA)
Juvenile Dermatomyositis (JD)
Systemic Lupus Erythematosus (SLE)
Juvenile Idiopathic Arthritis (JIA)
Systemic Lupus Erythematosus (SLE) in Children & Teens
Juvenile Scleroderma
Systemic Sclerosis
Kawasaki Disease
Temporal Arteritis
Lupus
Tendinitis
Lupus in Children & Teens
Vasculitis
Lyme Disease
Wegener’s Granulomatosis

Arthritis Types (4 of 100+)

types of arthritis in hand
Types of arthritis in hand. Seaweed appears to have an anti-inflammatory effect on osteo-arthritis and gout.
seaweed reduces arthritis in knees
Types of arthritis in knees. Seaweed anti-inflammatory seems to reduce pain but may be in earlier stage.
Seaweed reduces arthritis in the ankle with Pacific Seamoss
Various types of arthritis in the ankle
Extracts of seaweed reduce arthritis
Fig 3 from Myers et al [1] showing dose effects over time. The COAT Score is a comprehensive arthritis test comprised of four sub-scales: pain, stiffness, difficulty with physical activity and overall symptom severity,

References

[1] Myers, S. P., O’Connor, J., Fitton, J. H., Brooks, L., Rolfe, M., Connellan, P., Wohlmuth, H., Cheras, P. A., & Morris, C. (2010). A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis. Biologics : targets & therapy, 4, 33–44. https://doi.org/10.2147/btt.s8354

Categories
Biosea Health Health Benefits Pain Reduction

Natural Medicine for Joint Pain

Want a natural medicine for joint pain? One that is more effective than conventional analgesics or anti-inflammatories. In fact, medical practitioners advise against long term use of regular analgesics for joint pain. There are numerous remedies but the following 10 have proven trials. How much do you need? Most of these require a reasonable quantity consumed each day.

Joint pain, usually called arthritis (which means swollen joint) – in the back, hands, pelvis knees or ankles may be due to multiple causes. Some say that weight from obesity is the major cause – but more recently understanding is arthritis is primarily and inflammatory response. With over 104 different types of rheumatoid arthritis and osteoarthritis. (Read more here) it is not surprising that studies show various levels of pain relief. Not just with artificial drugs but also natural medicines.

Seaweed

Seaweed extracts such as fucoidan are effective. The fucoidan comes from brown seaweed, but red seaweed is effective and there is good evidence in animals and in humans that whole seaweed is even more effective. Should you take the whole plant or just an extract? Prof Lindsay Brown says the whole plant has various other nutrients and vitamins that have other benefits so you should eat the whole plant and forget the extracts. Customers have experienced remarkable reduction of arthritis from Pacific Seamoss.

SAM-e (S-adenosylmethionine)

SAM-e acts as an analgesic (pain reliever) and has anti-inflammatory properties. It may stimulate cartilage growth and also affects neurotransmitters, such as serotonin, which reduce pain perception. Two studies have shown that it relieves OA symptoms as effectively as non-steroidal anti-inflammatory drugs (NSAIDs) with fewer side effects and more prolonged benefit.

Indian frankincense – Boswellia serrate

The active components (Boswellic acids) have anti-inflammatory and analgesic (pain-relieving) properties. It also may help prevent cartilage loss and inhibit the autoimmune process. In a 2008 study, the extract, also known as Loxin 5, significantly improved OA pain and function within seven days. An Indian study also revealed it slowed cartilage damage after three months of use.

Osteo arthritis versus rheumotoid arthritis – courtesy of Grace and Able.

Capsaicin – Capsicum frutescens

Capsaicin temporarily reduces substance P, a pain transmitter. Its pain-relieving properties have been shown in many studies, including a 2010 study published in Phytotherapy Research, which revealed a 50 percent reduction in joint pain after three weeks of use. It is available as a topical cream, gel or patch

Tumeric/Curcumin –Curcuma longa

Curcumin is the chemical in turmeric that can reduce joint pain and swelling by blocking inflammatory cytokines and enzymes. A 2010 clinical trial using a turmeric supplement showed long-term improvement in pain and function in patients with knee OA. A small 2012 study using a curcumin product, BCM-95, showed more reduced joint pain and swelling in patients with active RA when compared to diclofenac sodium.

Avocado-soybean Unsaponifiables (ASU)

ASU blocks pro-inflammatory chemicals, prevents deterioration of synovial cells, which line joints, and may help regenerate normal connective tissue. A large three-year study published in 2013 showed that ASU significantly reduced progression of hip OA compared with placebo. A 2008 meta-analysis found that ASU improved symptoms of hip and knee OA, and reduced or eliminated NSAID use.

Cat’s Claw – Uncaria tomentosa

Cat’s claw is an anti-inflammatory that inhibits tumor necrosis factor (TNF), a target of powerful RA drugs. It also contains compounds that may benefit the immune system. A small 2002 trial showed it reduced joint pain and swelling by more than 50 percent compared with placebo. Look for a brand that is free of tetra-cyclic oxindole alkaloids.

Fish Oil (Omega-3 fatty acids EPA and DHA)

Omega-3s block inflammatory cytokines and prostaglandins, and are converted by the body into powerful anti-inflammatory chemicals called resolvins. EPA and DHA have been extensively studied for RA and dozens of other inflammatory conditions. A 2010 meta-analysis found that fish oil significantly decreased joint tenderness and stiffness in RA patients and reduced or eliminated NSAID use. Recent studies have shown it is little better than placebo.

Gamma Linolenic Acid (GLA)

GLA is an omega-6 fatty acid that the body converts into anti-inflammatory chemicals. In one trial, 56 patients with active RA showed significant improvement in joint pain, stiffness and grip strength after six months and progressive improvement in control of disease activity at one year. A smaller study found that a combination of GLA and fish oil significantly reduced the need for conventional pain relievers.

Ginger – Zingiber officinale

Ginger has been shown to have anti-inflammatory properties similar to ibuprofen and COX-2 inhibitors. In a 2012 study, a specialized ginger extract reduced inflammatory reactions in RA as effectively as steroids did. Earlier studies showed that taking a certain extract four times daily reduced osteoarthritis pain in the knee after three months of treatment, and another taken twice daily worked about as well as ibuprofen taken three times daily for hip and knee OA pain

Cannabidiol (CBD)

CBD is recent addition, and data is not yet clear. Cannabinoids are thought to influence the body’s own endocannabinoid system, which regulate biological functions such as metabolism, pain sensation and nervous system functions. Animal studies show CBD reduces pain and inflammation, and it may ease anxiety and improve sleep, but human research is needed. One study found synthetic-derived CBD was effective for knee OA pain. The FDA has approved CBD-derived drugs for rare childhood epileptic conditions.

Other Natural Products

There are many other natural medicines for relief of pain, and these include pine back extract, rosehips, and green lipped mussel extracts.

References

[1] Makkar, F & Chakraborty, K 2017, Antidiabetic and anti-inflammatory potential of sulphated polygalactans from red seaweeds Kappaphycus alvarezii and Gracilaria opuntia, International Journal of Food Properties, vol. 20, no. 6, pp. 1326-37.

[2] Kumar, S.A., Brown, L. Seaweeds as potential therapeutic interventions for the metabolic syndrome. Rev Endocr Metab Disord 14, 299–308 (2013). https://doi.org/10.1007/s11154-013-9254-8

[3] John O, Mouatt P, Prasadam I , Xiao Y, Panchal S, Brown L 2019 The edible native Australian fruit, Davidson’s plum (Davidsonia pruriens), reduces symptoms in rats with diet-induced metabolic syndrome, Journal of Functional Foods, (56) Pages 204-215, ISSN 1756-4646,
https://doi.org/10.1016/j.jff.2019.03.018.

[4] Kumar M & Sharma S (2020) Toxicological effects of marine seaweeds: a cautious insight for human consumption, Critical Reviews in Food Science and Nutrition, DOI: 10.1080/10408398.2020.1738334

[5] D’Orazio, N.; Gemello, E.; Gammone, M.A.; De Girolamo, M.; Ficoneri, C.; Riccioni, G. Fucoxantin: A Treasure from the Sea. Mar. Drugs 201210, 604-616.

[6] Tirtawijaya, G., Haque, M. N., Choi, J. S., Moon, I. S., Meinita, M. D. N., Choi, J.-S., & Hong, Y.-K. (2019). Spinogenesis and Synaptogenesis Effects of the Red Seaweed Kappaphycus alvarezii and Its Isolated Cholesterol on Hippocampal Neuron Cultures. Preventive Nutrition and Food Science, 24(4), 418. (PubMed)

[7] Wanyonyi, S., Du Preez, R., Brown, L., Paul, N. A., & Panchal, S. K. (2017). Kappaphycus alvarezii as a food supplement prevents diet-induced metabolic syndrome in rats. Nutrients, 9(11), 1261.(Pubmed)

[8] du Preez, R.; Paul, N.; Mouatt, P.; Majzoub, M.E.; Thomas, T.; Panchal, S.K.; Brown, L. Carrageenans from the Red Seaweed Sarconema filiforme Attenuate Symptoms of Diet-Induced Metabolic Syndrome in Rats. Mar. Drugs 202018, 97.

[9] Zakaria, A, Jais, MR & Ishak, R 2018, Analgesic properties of Nigella sativa and Eucheuma cottonii extracts  Journal of natural science, biology, and medicine, vol. 9, no. 1, p. 23.

[10] Myers SP, O’Connor J, Fitton JH, et al. A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis. Biologics. 2010;4:33-44. Published 2010 Mar 24. doi:10.2147/btt.s8354

[11] Sekar, S., Shafie, S., Prasadam, I. et al. Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats. Sci Rep 7, 46457 (2017). https://doi.org/10.1038/srep46457

[12] 10 Supplements for Arthritis Arthritis Foundation

Categories
Biosea Health FAQ

Is Seaweed Vegan

Seaweed is generally thought to be vegan, but the encapsulation means that the Pacific Seamoss gel capsules are not, whereas the Pacific Seamoss Powder is vegan and is in the process to formally certified organic and halal.

We will have a product available as a compressed tablet in 2021 to enable the capsule to be both vegan and halal.

If you are vegan then we suggest Pacific Seamoss powder is the solution fo you. The amount to take daily is 1/2 to1 teaspoon per day or about 3 grams of dry seaweed. The powder is vegan / organic – harvested from the sea, dried, milled, and packaged for freshness.

Overcoming the Taste of Seaweed

Dark Chocolate Treat

Some of our customers do not use capsules but Pacific Seamoss Powder. Add powder at 20% to dark chocolate. So it becomes a treat – bit like salted caramel. The chocolate recipe is here. (Chocolate).

Sourdough

Alternatively customers like sourdough and the recipe is here. They substitute the salt with Pacific Seamoss Powder. (Sourdough Recipe)

Au Natural

We have some customers that just apply the powder to their cereal or mashed spuds and say it is fine.
My cofounder says 2 of his kids are fine with fruit smoothies, but one notices and says its a bit gritty.

Is Seaweed Vegan?

Seaweed are technically not plants, but a type of algae. Algae are photosynthetic creatures, but are neither plant, animal or fungi. Being photosynthetic, algae, in the form of chlorella or spirulina, are widely accepted as suitable for supplementation in a vegan diet.

However, there is controversy in plant-based vegan communities regarding the composition of nori. Nori is a red algae genus Pyropia, including P. yezoensis and P. tenera, and Pacific Seamoss is also a red seaweed. Nori is often used to make sushi. The nets used in the harvesting process of nori are believed to scoop up small fish. Following this, seaweed, shrimp, crabs, snails, barnacles and small fish are ground together and made into nori sheets. The industry is so large that it often does not take the time to remove the sea animals.

In our harvesting methods, we grow seaweed on ropes, and in harvesting remove all visible sea creatures, but there will be small crustacea potentially in the dried product. Hence why we say do not consume seaweed if you have seafood allergies. The risk is small. For details see this blog on allergies.

Summary of Is Seaweed Vegan

Yes. For all practicable purposes.

Categories
Biosea Health Parkinsons Disease

Seaweed reduces Parkinson’s Disease Effects

There is no evidence seaweed can cure Parkinson’s Disease, but there is some good lab research showing that seaweeds may improve Parkinson’s Disease (PD) outcomes and anecdotal evidence from customers says seaweed reduces Parkinson’s Disease effects and improves the quality of life.

What is Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disorder that affects predominately dopamine-producing (“dopaminergic”) neurons in a specific area of the brain called substantia nigra. (Parkinson’s Foundation)

Image from Biolegend about the area of the brain affected.

Parkinson’s Disease is the second most common neurodegenerative disorder after Alzheimer’s disease (AD), affecting 1–2% of the population over age 60 estimated at over 10m globally. Individuals with genetically-linked familial forms of PD, represent less than 10% of the patients, and have an earlier onset of disease; occurring before the age of 40 or 50. PD is characterized by the progressive degeneration and loss of dopaminergic (DA) neurons in the substantia nigra of the midbrain and defined in part by the presence of intracytoplasmic inclusions called Lewy bodies (LBs).

Symptoms generally develop slowly over years. The progression of symptoms is often a bit different from one person to another due to the diversity of the disease. People with PD may experience:

  • Tremor, mainly at rest and described as pill-rolling tremor in hands. Other forms of tremor are possible
  • Slowness of movement or bradykinesia such as getting out of a chair
  • Limb rigidity
  • Gait and balance problems

Standard Treatment for Parkinson’s Disease

With no cure, treatment options vary and include medications and surgery. Levodopa, the most effective Parkinson’s disease medication, is a natural chemical that passes into your brain and is converted to dopamine. Standard medication is levodopa is combined with carbidopa, which protects levodopa from early conversion to dopamine outside your brain.

PD itself is not normally fatal but disease complications can be serious. 

Moreover, carers of PD patients can be very concerned that if they get unwell they will be unable to care for the PD sufferer.

What Causes  Parkinson’s Disease

There’s no single cause of PD. A variety of factors with complex interactions are thought to be responsible for both the disease’s development and progression. Years of research, suggests that while exact causes are unknown, the disease is caused by some combination of genetic predisposition and environmental factors, such as exposure to certain pesticides and heavy metals. Some genetic mutations appear to be inherited, such as in early-onset PD, but these affect only a small number of families, and not everyone who inherits the genetic mutation will develop the disease.

Populations that eat seaweed have less incidence of PD and other major diseases. (Cotas et al. 2020) (Peñalver et al. 2020) Some studies have shown that phycobiliproteins extracted from red algae (phycoerythrin) could be beneficial in the prevention or treatment of neurodegenerative diseases caused by oxidative stress (Alzheimer and Parkinson’s) due to their antioxidant effects (Bleakley and Hayes 2017) Some studies have looked at brown seaweeds (Silva et al. 2019) and the role of antioxidants in vitro. 

Seaweed reduces Parkinson’s Disease Symptoms

  • Fatigue
    • Seaweed increases energy – everyone reports more energy –
    •  Nutrient boost –  Potassium and other minerals.  
  • Constipation
    • Seaweed is 16% Soluble Fibre – feeds good gut bacteria  
    • Seaweed is 4% Insoluble fibre – bulk, helps reduce constipation  
    • Seaweed moderates smooth muscle action, making bowel movements easier . More information? Check out a blog on poo.
  • Dopamine availability  
    • Tyrosine is a precursor for dopamine –  makes more dopamine in the brain and seaweed has lots of these amino acids.
  • NADH availability  
    • NADH is necessary for energy production in the powerhouse (mitochondria) of the cells.   
    • Niacin (B3) is the precursor to NADH  
    • There is some theories that cells die because of the breakdown in these power systems  
    • Theory that increased Niacin in the diet slows cell death. 
    • Seaweed at 2.5g has 20% of daily Niacin – increasing seaweed intake is SAFE because it is a whole food. Full vitamin analysis is here. 

Seaweed is good for Parkinson’s Disease

  • Cell Regeneration  
    • Theory in vitro –  Increased Numbers of neurons in brain  
    • Theory in vitro –  Increase Connections between neurons  
    • Reduces cognitive decline associated with accelerated ageing in the brain. Japanese population studies.   
  • Liver Cleanse   
    • Seaweed reduces liver build up  
    • Makes metabolism of both medicines and nutrients easy   
    • Better delivery of nutrients to cells  
    • Reduce build up from secondary products found in medication fillers  
  • Packed with Natural Nutrients  
    • Bioavailable and not toxic  
    • High in antioxidants  
    • High in plant sterols   
    • Reduce secondary effects of disease and medications – inflammation in cells and joints.   
  • Seaweed Is Safe  
    • All studies show NO adverse effects  
    • No behavior changes  
    • No psychological changes  
  • Iodine   
    • Natural form of iodine  
    • In amounts that are GOOD for thyroid function   
    • Restore thyroid function = healthy metabolism.

Conclusion – Seaweed is Very Promising

Bioactive compounds isolated from red, green and brown seaweeds possess immense immune potential with commendable medicinal activity and high nutritive value contributed by their unique chemical structures and molecular integrity. Venkatesan et al 2016 strongly suggest the importance of seaweed bioactive compounds in health and diseased conditions and the future exploration of seaweeds for neurological diseases, especially Parkinson’s Disease.

References

  1. Bleakley, Stephen, and Maria Hayes. 2017. ‘Algal Proteins: Extraction, Application, and Challenges Concerning Production’. Foods 6 (5). https://doi.org/10.3390/foods6050033.
  2. Cotas, João, Adriana Leandro, Diana Pacheco, Ana M. M. Gonçalves, and Leonel Pereira. 2020. ‘A Comprehensive Review of the Nutraceutical and Therapeutic Applications of Red Seaweeds (Rhodophyta)’. Life 10 (3): 19. https://doi.org/10.3390/life10030019.
  3. Peñalver, Rocío, José M. Lorenzo, Gaspar Ros, Ryszard Amarowicz, Mirian Pateiro, and Gema Nieto. 2020. ‘Seaweeds as a Functional Ingredient for a Healthy Diet’. Marine Drugs 18 (6). https://doi.org/10.3390/md18060301.
  4. Silva, Joana, Celso Alves, Rafaela Freitas, Alice Martins, Susete Pinteus, Joana Ribeiro, Helena Gaspar, Amparo Alfonso, and Rui Pedrosa. 2019. ‘Antioxidant and Neuroprotective Potential of the Brown Seaweed Bifurcaria Bifurcata in an in Vitro Parkinson’s Disease Model’. Marine Drugs 17 (2): 85. https://doi.org/10.3390/md17020085.
  5. ‘What Is Parkinson’s? | Parkinson’s Foundation’. n.d. Accessed 17 December 2020. https://www.parkinson.org/understanding-parkinsons/what-is-parkinsons.
  6. Venkatesan, Manigandan, Karthik Ramachandran, Saravanan Ramachandran, Subburaj Jayachandran, and Barath TR. 2016. ‘Ameliorative Role of Marine Seaweed Bioactives against Parkinson’s Disease’. In Food and Parkinson’s Disease.