Categories
Biosea Health Cancer Reviews

Seaweed Protects Against Lung Cancer

Prebiotics, including seaweed, and probiotics (yoghurt) prevent lung cancer. How can this be true? Not convinced that seaweed protects against lung cancer. A 2019 study in the Journal of American Medical Association showed prebiotics, including seaweed, and probiotics (yoghurt) have a role in the prevention of lung cancer[1].

How can the gut and the lungs be linked?

The relationship between the gut microbiota and overall health and wellbeing is now well established. Metabolites from the microorganisms, including short chain fatty acids, trigger changes in metabolic pathways throughout the body. It has previously been shown that gut microbiota can influence inflammation in the lungs [2] and also improved lung function in Chronic Obstructive Pulmonary Disease (COPD) [3]

Prebiotics and Probiotics – the difference.

Prebiotics are also known as soluble fibre. They are foods that dissolve when eaten to create a viscous gel that is readily digested by the good bacteria in the colon. This type of fibre is found in legumes and fruit. Prebiotics are different to cellulose rich insoluble fibre which is found in grains and vegetables. These are not digested, but act as bulk to enable bowel movements and prevent constipation.

Probiotics are foods or supplements that already contain a component of bacteria or other micro-organisms. Probiotics deliver bacteria to the lower intestines to improve the ratio of good to bad bacteria. Yoghurt is the most common example of this, but other probiotic foods include kombucha, kefir, miso and sauerkraut.

Peer-reviewed Studies Showing Seaweed protects against Lung Cancer

Scientists from around the world published the study in the Oncology Section of the Journal of the American Medical Association in October 2019.

The aim of the study was to assess the effect of individual or combined prebiotic and yoghurt intake on lung cancer risk. The positive effects from prebiotics and probiotics, specifically yoghurt, have been well documented in the past. Both create health benefits by modulation of gut microbiota and metabolic pathways. However, little research had been done to examine the effect of prebiotic and yoghurt intake on the development of lung cancer.

In this massive study data from 1.4 million participants from America Europe and Asia was collected over a period of 8 years. Scientists looked at fibre intake, yoghurt consumption and other known risks including age, smoking status, obesity and much more.

Results showed that both the prebiotic fibre and yoghurt decreased the risk of lung cancer by just under 20% each. But surprisingly, when prebiotic fibre and yoghurt were combined the risk reduction rose to 30%. This suggests a synergistic effect between prebiotics and probiotics.

Prebiotic Seaweed Protects Against Lung Cancer

Pacific Seamoss has a carbohydrate content of 38 percent, of which 34 percent is prebiotic soluble fibre. Pacific Seamoss, like other functional foods, has a wide variety of beneficial health effects because of its high prebiotic activity. It is the metabolites from the good bacteria which cross into the blood stream to create medicine-like effects throughout the body and improve overall health and resistance to disease.

This study suggests that Pacific Seamoss also confers a reduced risk of lung cancer, up to 30 percent if you are a regular yoghurt eater as well.

But I don’t smoke, so I don’t need to worry about lung cancer

“Unfortunately, this is a myth. 45% of females who get lung cancer don’t smoke”

Smoking is still the major cause of lung cancer accounting for about 90 percent of cancers in males but only 65 percent in females. Secondhand smoke is also a leading cause. But there is a high percentage of lung cancer cases that have no known origin and may be genetically linked or just related to getting older.

Lung Cancer is the Leading Cause of Cancer Deaths

Lung cancer is the 4th most common cancer but the most deadly. While more people are diagnosed with other cancers, including breast, colorectal, skin and prostate cancers, lung cancer is the deadliest with about 9,000 people dying each year in Australia and about 12,000 new diagnoses each year. [4]

The following figure shows that most people are not diagnosed until they are at stage IV, and the 5-year survival rates are terrifyingly close to zero at 3.2%. If diagnosed early as few are, then survival is about 65%.[4]

The 10 most common cancers are shown in the Table below.

From AIHW: Cancer in Australia 2019.

Seaweed Protects Against Lung Cancer – What We Recommend

The ratio of good to bad microorganisms in the colon changes when we change our diet. This study showed that daily consumption of prebiotic soluble fibre will reduce lung cancer risk, and this effect will be greater if a probiotic is also consumed.

We recommend a daily intake of the functional food capsules of Pacific Seamoss because seaweed protects against lung cancer and therefore while it has maximum prebiotic benefits, it also has high nutrient and nutraceutical content. Add your favourite low sugar yoghurt to your diet and not only are you enjoying your food, you are doing something positive for your long term health.

Both your gut and your family will love you for it.

References

[1] J. J. Yang et al., “Association of Dietary Fiber and Yogurt Consumption With Lung Cancer Risk: A Pooled Analysis,” JAMA oncology, 2019. (Abstract here)
[2] J. P. McAleer and J. K. Kolls, “Contributions of the intestinal microbiome in lung immunity,” European journal of immunology, vol. 48, no. 1, pp. 39-49, 2018. (Publication here)
[3] H. Kan, J. Stevens, G. Heiss, K. M. Rose, and S. J. London, “Dietary fiber, lung function, and chronic obstructive pulmonary disease in the atherosclerosis risk in communities study,” American journal of epidemiology, vol. 167, no. 5, pp. 570-578, 2008. (Publication Here)
[4] A. I. o. Health and Welfare, “Cancer data in Australia,” AIHW, Canberra2019, Available: https://www.aihw.gov.au/reports/cancer/cancer-data-in-australia.

Categories
Biosea Health Gut Microbiome Health Benefits Reviews

Seaweed Reverses Metabolic Syndrome

Rats fed seaweed reverses metabolic syndrome caused by a junk food diet. Sounds too good to be true?  Professor Brown was astonished. This animal study was published in 2017 but few seem to understand the ramifications.  You can negate a junk food diet with seaweed. Alternatively, you will be able to reverse the ill-health effects of a bad diet.

The Trial

Professor Lindsay Brown University of Southern Queensland supervised this PhD study along with Dr Sunil Pachal at the University of Southern Queensland.  The paper is listed below.

They took rats and fed some of them on an junk food (extra sugar + fat) diet.  Just like in the movie Super Size Me, a 2004 American documentary film directed by and starring Morgan Spurlock. Spurlock’s film follows a 30-day period from February 1 to March 2, 2003, during which he ate only McDonald’s food. The film documents this lifestyle’s drastic effect on Spurlock’s physical and psychological well-being. If you want to see what a human on junk food diet looks like. Or not.

Professor Brown’s trial had 3 groups of 10 rats each.  Group 1 had normal rat diet. Group 2 had a Junk food diet. Group 3 had the junk food diet plus some seaweed (Kappaphycus sp) .  The trial went for 8 weeks.

Outcomes

This data is taken directly from the peer reviewed published paper, and highlights a few key metrics. There are other more complicated conclusions as well.

Seaweed Reverses Metabolic Syndrome:Weight 

Normal          Supersize Supersize+ Seaweed
Final Weight g

350

431

348 

Energy Intake kJ/day

38

23

21

Feed conversion efficiency g/Kj   

0.04

0.2

0.03

Fatness

Indicator     Normal       Supersize Supersize+ Seaweed
Circumference cm 

18.4

20.5

18.9

Abdominal Fat mg/mm     

342

632

337

Total Fat Mass Times 

49

98

53

Bone Density

Indicator  Normal      Supersize    Supersize+ Seaweed
Bone Mineral Density  g/cm2

10

12

10

Blood Measures

Indicator Normal         Supersize Supersize+ Seaweed
Basal Blood Glucose mmol/L

3.7

4.7

3.6

Total Glucose mmol/L.min

650

800

753

Triglycerides  mmol/L

0.6

1.7

1.3

Systolic Blood Pressure mm

120

136

127

NO WEIGHT GAIN. WHY NOT?

blood pressure control with seaweed dietary supplement also stopped any weight gain from junk food
From Wanyonyi 2017. The rats on the junk food + seaweed were no different in weight than the standard diet, in contrast to rats on a junk food diet.

BLOOD GLUCOSE BACK TO NORMAL

blood glucose control with seaweed dietary supplement
From Wanyonyi 2017. Blood glucose controlled with seaweed provided as a dietary supplement.

Additional Measures

  • Gut microbiota diversification profiling
  • Metal and metalloid liver analysis
  • Histology
  • Organ weights
  • Body composition
  • Fatty liver disease reversal
  • Gut microbiome reverts to normal
  • Gut inflammation eliminated.
  • Damage to the heart was reversed.

BLOOD PRESSURE. NO HYPERTENSION

Blood pressure control with seaweed dietary supplement reduces liver inflammatory cells
From du Preez 2020. Seaweed markedly reduces liver inflammatory cells in less than 8 weeks. The damage is completely mitigated by the seaweed.

GUT MICROBIOME CHANGES

gut microbiome changes are the likely reason that blood pressure control with seaweed dietary supplments worked.
Figure from Waynonyi 2017. The microbiome was radically changed with the introduction of Kappaphycus alvarezii to the diets of the junk food animals.

Conclusion

Professor Brown was astonished.  The introduction of seaweed did not reduce the symptoms a little. The seaweed had such a dramatic effect it was if these rats had not eaten the junk food diet. What was going on?

References

[1] Wanyonyi, S; du Preez, R; Brown, L; Paul, N; Panchal, S  2017 Kappaphycus alvarezii as a Food Supplement Prevents Diet-Induced Metabolic Syndrome in Rats. Nutrients (9) 11 DOI:10.3390/nu9111261 (Click for Abstract) (Click to download full paper)

Categories
Biosea Health Gut Microbiome Heart Health Seaweed for Humanity

Experience backed by Science

Is consumer experience backed by science?  What we are looking for is that science provides validation for personal experiences. Seaweed improves health. Scientists know why your blood pressure improves by 15mm Hg. Long term science backs up personal  health improvement. However, one cannot make any health claim. Because the regulatory industry was established for artificial drugs and medicines, and functional foods struggle for registration and have to be tested in human and animal clinical trials.

There are some clinical trials on humans. There are thousands of peer reviewed publications on the health improvements in vitro, in animals and for limited studies, humans. Google Search for “seaweed functional food” returns 3.5 million hits.

Is Experience Backed By Science?

Discussion and peer reviewed publications with

  • Professor Lindsay Brown University of Southern Queensland (been doing research for 20 years on superfoods)
  • Professor Jane Teas Southern Carolina University
  • Dr Jan Villasend – Aarhus University Hospital in clinical research arthritis in Denmark
  • Dr Monique Mulder Erasmus University Medical Center Rotterdam, The Netherlands.

Our “Pacific Seamoss” red seaweed is 35% sulfated polysaccharide and is pretty indigestible, and passes through the stomach into the intestines. The microbiome get busy on it and composition changes and protects the lining. As well as the extra fibre, and normalisation of the bacteria, some of the other 1000 compounds in the seaweed get absorbed. Some of the compounds have been identified and implicated in the beneficial effects. (eg fucoidan) but there are many unknowns on the mechanism.

Some brown seaweeds (Kelp, Dulce) have an issue with iodine levels too high so you cannot eat the 5+ grams per day of seaweed. The five grams is a daily serve of veges.
Is there a major difference between seaweeds. Possibly if you refine them. But if you have them whole there may not be due to the very complicated interactions.

Metabolic Syndrome Clinical Trial with Humans – 2013

Prof Jane Teas. Did a human double blind clinical trial on 40 overweight volunteers who were already on blood pressure tablets and statins. They all had metabolic syndrome so they all had 2 of those symptoms – Hypertension, weight, high cholesterol and sugar intolerance. They were given 5gm of seaweed, between 4 and 8 gm depending on the treatments.

Significant Outcome. Blood pressure was down 10mm Hg. Patients lost on average 3 kg. There was a reduction in type 2 diabetes. Their cholesterol went down by 2 whole points.  The attached paper has more details.

Animal Studies Obesity Fats Rats made Thin 2017

Professor Lindsay Brown from University of Southern Queensland / UQ has been doing functional food research for 15 years on animals. They did do some human trials on Queen Garnet Plums through Univ Victoria with Nutrafruit.com.au. Over his research spanning 2 decades and multiple products, including purple fruits (with anthrocyanin), purple carrots, purple plums, purple corn and also on linseed, and more recently on seaweed with various species the results are the same.

  • Improvement of gut microbiome
  • Reduction or elimination of fatty liver
  • Bone density increase
  • Blood pressure reduction
  • Weight loss reduction
  • Cartilage increase .

What is interesting that essentially fatty liver disease is gone, heart fibrous tissue gone, cholesterol down and good DNA data from the gut microbiome returning to normal.

Prof Brown’s conclusion is that there is no real difference between the whole food and if you try to split out the active compounds. They had done the work for the purple plum and the outcomes were the same for the whole food versus the identified other compounds.

Some of his work has been documented in the media.

Diabetes

Prof Brown’s work with rats over the past 15 years shows all of these conditions improve with the super food. Be it purple carrots, linseed, Purple Garnet Plums, Purple Corn, Achacha (Garcinia humalis) Mangostem, Seaweed. As consumers start to eat seaweed daily then it is clear that consumer experience backed by science, and the challenge is to undertake more science on humans that continue to do work on animal studies.

Fatty Liver and Kidney Disease

In the animal studies Lindsay showed reversal of metabolic syndrome and that fatty liver disappear and kidney function returns.

Breast Cancer – Humans 2013

A short single blind trial by Jane Teas in 2013. Only 16 people, all breast cancer survivors and only for 12 weeks. 4 weeks placebo, 4 weeks 5 gm Unadaria (a brown). The Creatinine levels halved. Creatinine is a marker of inflammation and more importantly implicated in breast cancer. . She was looking to explain why Japanese women have 1/10 breast cancer rates of those in USA

“uPAR is higher among postmenopausal women generally, and for BC patients, it is associated with unfavorable BC prognosis. By lowering uPAR, dietary seaweed may help explain lower BC incidence and mortality among postmenopausal women in Japan. “

There is other animal and invitro studies and it shows that in mice the oestrogen was stripped out. See this blog

Dementia 2019

Prof Brown says animal studies in dementia do not translate well into humans and that 1 drug out of 200 is the track record to date. But Dr Monique Mulder with Sargassum (brown) and others published in Nature in March 2019 that Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer’s disease mouse model. The thing seems to be multi-modal in that it provides plant sterols to the brain crossing the blood brain barrier, and stops amyloid plaques and tangles. And reverses it in mice. They are moving from animals to humans in their trials.

Rheumatoid Arthritis and Bowel Inflammation

Dr Jan Villadsen got given some seaweed/rapeseed/fermented mix from FermBiotics.com from his University friend Dr Belinda Bjerre who is a Project Diretor on some of the EU seaweed research programs. The mix was to developed to eliminate use of zinc oxide and antibiotics in pig production. The pig studies show equivalence or better than conventional Zn+antibiotic treatments. Note: zinc is banned in EU animal feed from 2022. A long term rheumatic arthritis (RA) sufferer, Dr Villadsen’s C-Reactive Protein goes to zero in 17 days. Patent. Publications. He and colleagues at Aarhaus are now doing a clinical trial with 200 patients on IBS and RA .

Osteo Athritis

We don’t know exactly which of the 100 different types of arthritis seaweed will work on. There is consistent strong anecdotal evidence. There is in vitro studies. A Nature publication from Prof Xiao and Prof Brown [6] demonstrated when they took the rats from Browns metabolic studies and they identified collagen and connective growth recovery in the rats. This is similar to the osteoarthritis work with extracted fucoidan extracts from brown seaweed.

Conclusion

Functional foods can provide health benefits by reducing the risk of chronic diseases and enhancing the ability to manage chronic diseases, and improving the quality of life. This gives seaweed great potential as a supplement in functional food or for the extraction of compounds.

Our company has a challenge to accelerate the clinical trials and register the benefits to be able to make health claims. Pacific Seamoss is just food. But make your own judgement. No one is stopping you eat food. Even nail growth! We have people where their nails grow more and this is a prime experience backed by science over 11 years ago.

References

[1] Wanyonyi, S; du Preez, R; Brown, L; Paul, N; Panchal, S  2017 Kappaphycus alvarezii as a Food Supplement Prevents Diet-Induced Metabolic Syndrome in Rats. Nutrients (9) 11 DOI:10.3390/nu9111261 (Click for Abstract) (Click to download full paper)

[2] Teas, J et al  2009 Could dietary seaweed reverse the metabolic syndrome? Asia Pac J Clin Nutr 18 (2) 145-157 (Click for Abstract) (Click to download full paper)

[3] Teas, J et al 2013 The consumption of seaweed as a protective factor in the etiology of breast cancer: proof of principle. J Appl Phycol 25 771-779  DOI:10.1007/s10811-012-9931-0 (Click for Abstract) (Click to download full paper)

[4] Bogie, J et al (Including Monique Mulder) 2019 Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer’s disease mouse model. Scientific Reports 9 (1) DOI 10.1038/s41598-019-41399-4 (Click for Abstract) (Click to download full paper)

[5] Villasend J;  Silkeborg R 2019 Clinical trial: Investigation of macroalgae as a synbiotic adjuvant in chronic inflammatory diseases. Seagriculture19 Belgium presentation  (Click to download presentation)

[6] Sekar, S., Shafie, S., Prasadam, I. et al. Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats. Sci Rep 7, 46457 (2017). https://doi.org/10.1038/srep46457

Media

  • https://www.abc.net.au/local/archives/landline/content/2016/s4419411.htm
  • https://www.abc.net.au/local/archives/landline/content/2015/s4180101.htm
  • https://www.abc.net.au/news/2017-07-15/sleeping-giant:-linseeds-health-properties-could/8711970