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Breast Cancer Rates 1/10 of UK. Why?

Breast cancer rates in UK are 10 times those of Japan. USA has 4 times rate of mortality than Japan. Why? Diets, and eating seaweed is just one of differences implicated. This wide difference has intrigued researchers and other studies have followed from this remarkable difference.

Breast Cancer Rates in UK are Higher

Breast cancer rates in UK are 10 times those of Japan. USA has 4 times rate of mortality than Japan. Why? Diets, and eating seaweed is just one of differences implicated. This  wide difference has intrigued researchers and other studies have followed from this remarkable difference.

The rates of Japanese versus UK, France and Spain are even more pronounced.

Another interesting comparison is the rates of breast cancer in Japan versus the rates of breast cancer in the USA over 25 years.

This graph from Kotanda and Hori in 2016 assessed breast cancer incidence rates between Japanese in Japan and those in the USA.  The full details of how they made are in the reference below. They used aged-standardized incidence rates (called ASR) and the data is from 1959 to 2007.  Conclusions were.

  •  The ASRs of the three prefectures in Japan have been increasing.
  • The ASRs in the USA also showed increasing trends
  • ASR for Japanese are lower than Americans throughout the 50 years
  • The Japanese are slowly catching up on the Americans

The figure below shows more data.

The question is why? What is different about the society that causes this markedly different cancer rates.

Breast Cancer Markers Halved with Seaweed

Professor Jane Teas was looking for this as early as 1981 but went on with a clinical trial of 16 women post breast cancer detection and treatment in 2013. Her conclusions from that paper is that one marker of breast cancer is particular chemical in the blood called uPAR (Urinary human urokinase-type plasminogen activator receptor).

“One serum protein (m/z 8,928) reversibly increased with seaweed and may be the immunostimulatory complement activation C3a des-arginine. uPAR is higher among postmenopausal women generally, and for BC patients, it is associated with unfavorable BC prognosis. By lowering uPAR, dietary seaweed may help explain lower BC incidence and mortality among postmenopausal women in Japan”.

Plain English: Seaweed halved a marker of breast cancer in less than 4 weeks. That marker can be identified in blood tests and the uPAR is called creatinine.

Here is the image from the publication.  For more information head to the references by Jane Teas 2013. We now know seaweed is good for you.

References

  • Kota Katanoda, Megumi Hori 2016. Incidence rate for breast cancer in Japanese in Japan and in the United States from the Cancer Incidence in Five Continents. Japanese Journal of Clinical Oncology, Volume 46, Issue 9, September 2016, Page 883, https://doi.org/10.1093/jjco/hyw119 and Oxford University Press
  • Saika, K., & Sobue, T. (2009, January). Epidemiology of breast cancer in Japan and the US. Japan Medical Association Journal.
  • Teas J. The consumption of seaweed as a protective factor in the etiology of breast cancer. 1981 Medical Hypotheses DOI 10.1016/0306-9877(81)90004-9
  • Teas, Jane; Vena, Sylvia; Lindsie, D; Irhimeh, Mohammad 2013 The consumption of seaweed as a protective factor in the etiology of breast cancer: proof of principle DOI: 10.1007/s10811-012-9931-0